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KMID : 0365819710110020189
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Journal of Pusan Medical College
1971 Volume.11 No. 2 p.189 ~ p.196
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Effects of Partial ilepatectoiny on Storage Iron Metabolism in Rabbits
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Abstract
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The author investigated the effect of partial hepatectomy on the metabolism of tissue storage iron. Rabbits were used in this study. The partial hepatectomy was performed by removing one fourth of or half of the total liver tissue by peritoneal approach in normal rabbits. In the rabbits with partial hepatectomy were followed by chemical method, changes in the storage iron concentration of the remaining liver, spleen, kidney and bone marrow, and those in plasma iron concentration. The results thus obtained were discussed and the following conclusions were drawn.
1. In the rabbits with massive resection of liver tissue by partial hepatectomy there increased the storage iron concentrations of the remaining liver, spleen, kidney and bone marrow. In such cases both the concentratian of hemosiderin iron and that of ferritin iron increased in the remaining liver, spleen and brie marrow, but in the renal cortex the ferritin iron concentration increased predominantly and in the renal medulla the homosiderin iron concentration predominantly.
2. In the rabbits with massive resection of liver tissue the plasma iron concentration tended to decrease.
On the basis of the above results it may be suggested that a profound disturbance in storage iron metabolism occurs in the animals with massive resection of hepatic parenchyma.
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